The Swiss come into the World Cup off the back of a quarter-final run at Euro 2020, while Cameroon finished third at the Africa Cup of Nation.
After four consecutive international tournaments, it will take some getting used to seeing Switzerland without Vladimir Petkovic on the touchline, as former Schaffhausen boss Murat Yakin takes the national side to a World Cup for the first time.
Since taking over in August 2021, the Basler has overseen a remarkably successful World Cup qualifying campaign, remaining unbeaten with 18 points from a possible 24 to top the group ahead of Italy.
Cameroon, on the other hand, have struggled for form since their Africa Cup of Nations run, winning just one of their last five, with that victory coming against 141st-ranked Burundi.
Rigobert Song's men qualified for Qatar in dramatic fashion, as Karl Toko Ekambi broke Algerian hearts to qualify for their eighth World Cup back in March.
The Indomitable Lions are actually the fourth-lowest ranked side in the entire tournament, finding themselves 28 places behind their Swiss opponents, and 22 adrift of anyone else in Group G.
Switzerland vs Cameroon confirmed line-ups
Switzerland XI (4-2-3-1): Sommer; Rodriguez, Akanji, Elvedi, Widmer; Xhaka, Freuler; Shaqiri, Sow, Vargas; Embolo
Cameroon XI (4-3-3): Onana; Tolo, Nkoulou, Castelletto, Fai; Gouet, Anguissa, Honglo; Choupo-Moting, Mbeumo,Toko Ekambi